Dydrogesterone

Description

Simple description:
Product Name: Dydrogesterone
CAS: 152-62-5
Melting point 168-173°C
alpha D25 -484.5° (chloroform)
Boiling point 392.36°C (rough estimate)

Brief introduction:
The trade name of Dydrogesterone: Dufu Tong, is an oral Progestogen preparation. It is a natural oral Progestogen with little side effects, no androgen and Adrenocortical hormone effects, and no effect on lipid metabolism. Dydrogesterone has other functions in addition to the well-known role of fetal protection
Indications:
Dydrogesterone is an oral Progestogen, which can be used for various diseases with insufficient endogenous Progestogen, such as dysmenorrhea, Endometriosis, secondary amenorrhea, irregular Menstrual cycle, dysfunctional uterine bleeding, premenstrual syndrome, premenstrual abortion or habitual abortion caused by Progestogen deficiency, infertility caused by luteal chemobook deficiency. Dydrogesterone is used to supplement Progestogen, It can be used to treat various diseases caused by endogenous Progestogen deficiency, such as threatened or habitual abortion caused by Progestogen deficiency, infertility caused by luteal insufficiency, dysmenorrhea, amenorrhea, irregular menstruation, Abnormal uterine bleeding, premenstrual syndrome, etc.

Other:
Bioactive Progestogen (NSC 92336) is an orally effective progesterone that directly acts on the uterus and produces complete secretory endometrium in the estrogen pretreated uterus.In vitro studies on the effects of dihydrosterone alone or in combination with estrogen on endothelial cells have a neutral effect on NO synthesis and eNOS activity and expression. In vivo studies have shown that Hydrogesterone eliminates the increased miscarriage rate caused by stress in mice. Hydrogestrone restored the percentage of CD8+uterine cells to the level of control mice. Hydrogesterone significantly reduced TNF in mice after 7.5, 9.5, and even 10.5 days of action- α The relative number of uterine cells produced. Hydrogesterone acts on stress mice, causing an increase in the percentage of ICHEMICAlbookL-4+uterine cells for pregnancy protection after 7.5 days of pregnancy, or even more significantly, and this increase persisted until 10.5 days. Hydrogesterone eliminated the increased miscarriage rate in mice under sound pressure. Hydrogesterone acts on stressed mice to increase the plasma PIBF level, but does not affect the Progestogen level. Hydrogesterone significantly increased the percentage of IL-4 positive decidual immune cells in stressed mice. Side effects Use of Dydrogesterone may bring some side effects: slight bleeding, menstrual blood volume change, amenorrhea; Vomiting and abdominal pain; Liver function changes and jaundice (rare); Breast pain, etc.

PS: Other progesterone and derivatives available